Recent advances of smart materials for ocular drug delivery

Xiaojun Wang; Fuxiao Luan; Hua Yue; Cui Song; Shuang Wang; Jing Feng; Xiao Zhang; Wei Yang; Yuxin Li; Wei Wei; Yong Tao

doi:10.1016/j.addr.2023.115006

Recent advances of smart materials for ocular drug delivery

Adv Drug Deliv Rev. 2023 Sep:200:115006. doi: 10.1016/j.addr.2023.115006. Epub 2023 Jul 13.

Authors

Xiaojun Wang¹, Fuxiao Luan¹, Hua Yue², Cui Song², Shuang Wang², Jing Feng³, Xiao Zhang², Wei Yang², Yuxin Li¹, Wei Wei⁴, Yong Tao⁵

Affiliations

¹ Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, PR China; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
² State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
³ Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, PR China.
⁴ State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China. Electronic address: weiwei@ipe.ac.cn.
⁵ Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, PR China. Electronic address: taoyong@bjcyh.com.

PMID: 37451500
DOI: 10.1016/j.addr.2023.115006

Abstract

Owing to the variety and complexity of ocular diseases and the natural ocular barriers, drug therapy for ocular diseases has significant limitations, such as poor drug targeting to the site of the disease, poor drug penetration, and short drug retention time in the vitreous body. With the development of biotechnology, biomedical materials have reached the "smart" stage. To date, despite their inability to overcome all the aforementioned drawbacks, a variety of smart materials have been widely tested to treat various ocular diseases. This review analyses the most recent developments in multiple smart materials (inorganic particles, polymeric particles, lipid-based particles, hydrogels, and devices) to treat common ocular diseases and discusses the future directions and perspectives regarding clinical translation issues. This review can help researchers rationally design more smart materials for specific ocular applications.

Keywords: Drug delivery; Ocular diseases; Smart materials.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials*
Drug Delivery Systems*
Humans
Pharmaceutical Preparations
Polymers

Substances

Biocompatible Materials
Polymers
Pharmaceutical Preparations