A novel benzo hemicyanine-based fluorescent probe for susceptible visualizing detection of phosgene

Sufang Shao; Cheng Bao; Baocheng Zhou; Yifeng Han

doi:10.1016/j.talanta.2023.124912

A novel benzo hemicyanine-based fluorescent probe for susceptible visualizing detection of phosgene

Talanta. 2023 Dec 1:265:124912. doi: 10.1016/j.talanta.2023.124912. Epub 2023 Jul 4.

Authors

Sufang Shao¹, Cheng Bao¹, Baocheng Zhou¹, Yifeng Han²

Affiliations

¹ Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
² Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, 310018, China. Electronic address: zstuchem@gmail.com.

PMID: 37451118
DOI: 10.1016/j.talanta.2023.124912

Abstract

Leakage and misuse of phosgene, a common and highly hazardous industrial chemical, have always constituted a safety risk. Therefore, it is crucial to develop sensitive detection methods for gaseous phosgene. This work describes the design and development of a new fluorescent dye based on benzohemicyanine, as well as the synthesis of fluorescent probes for the sensitive detection of gaseous phosgene. Due to the excellent intramolecular charge transfer (ICT) effect from the strong electron-donating impact of the o-aminophenol group on benzo hemicyanine, the probe does not emit fluorescence. When the probe reacts with phosgene, the ICT effect is inhibited, and the result exhibits observable green fluorescence, thereby visualizing the response to phosgene. The probe offers exceptional sensitivity, a rapid response, and a low phosgene detection limit. In addition, we developed probe-loaded, portable test strips for the quick and sensitive detection of phosgene in the gas phase. Finally, the constructed probe-loaded test strips were utilized effectively to monitor the simulated phosgene leakage.

Keywords: Fluorescence probe; Hazardous industrial chemicals; Phosgene leakage; Sensitive detection.