Multi-focus image fusion is a method to extend the depth of field to generate fully focused images. The effective detection of image focusing pixels and the optimization of image regions are the key to it. A method based on multidimensional structure and edge-guided correction (MSEGC) is proposed. The pixel-level focusing evaluation function is redesigned to preserve image details and non-texture regions. Edge-guided decision correction is used to suppress edge artifacts. With public data and semiconductor detection images for verification, the results show that compared with other methods, the objective evaluation is improved by 22-50%, providing better vision.