Liquid Biopsy in Adverse Neurodevelopment of Children: Problems and Prospects

Abstract

Neurodevelopmental disorders in children have an important impact on the quality of life in the whole life cycle. Severe neurodevelopmental disorders will become a serious social and family burden and an important social and economic problem. The early and middle childhood is the critical period of children's neurodevelopment. Early diagnosis of neurological disorders plays an important role in guiding children's neurological development. Existing monitoring tools lack prenatal and even early assessment of children's neurodevelopment, so reliable biomarkers are conducive to personalized care at an earlier stage. In this review, we will discuss different methods of neurodevelopmental monitoring at different times and the role and evaluation of liquid biopsy in neurodevelopmental monitoring.

Keywords: Attention-deficit/hyperactivity disorder (ADHD); Autism spectrum disorder (ASD); Birth weight (BW); Developmental delay (DD); Early diagnosis; Intellectual disability (ID); Neurodevelopmental disorder.