Recent advancements in "phyco-nanobionics" have sparked considerable interest in the ability of microalgae to synthesize high-value natural bioactive compounds such as carotenoid pigments, which have been highlighted as an emergent and vital bioactive compound from both industrial and scientific perspectives. Such bioactive compounds are often synthesized by either altering the biogenetic processes existing in living microorganisms or using synthetic techniques derived from petroleum-based chemical sources. A bio-hybrid light-driven cell factory system was established herein by using harmful macroalgal bloom extract (HMBE) and efficient light-harvesting silver nanoparticles (AgNPs) to synthesize HMBE-AgNPs and integrating the synthesized HMBE-AgNPs in various concentrations (1, 2.5, 5 and 10 ppm) into the microalgae C. sorokiniana UUIND6 to improve the overall solar-to-chemical conversion efficiency in carotenoid pigment synthesis in microalgae. The current study findings found high biocompatibility of 5 ppm HMBE-AgNP concentration that can serve as a built-in photo-sensitizer and significantly improve ROS levels in microalgae (6.75 ± 0.25 μmol H2O2 g-1), thus elevating total photosynthesis resulting in a two-fold increase in carotenoids (457.5 ± 2.5 μg mL-1) over the native microalgae without compromising biomass yield. NMR spectroscopy was additionally applied to acquire a better understanding of pure carotenoids derived from microalgae, which indicated similar peaks in both spectra when compared to β-carotene. Thus, this well-planned bio-hybrid system offers a potential option for the cost-effective and long-term supply of these natural carotenoid bio-products.