Partially hydrolyzed guar gum suppresses the progression of pulmonary arterial hypertension in a SU5416/hypoxia rat model

Takayuki J Sanada; Koji Hosomi; Jonguk Park; Akira Naito; Seiichiro Sakao; Nobuhiro Tanabe; Jun Kunisawa; Koichiro Tatsumi; Takuji Suzuki

doi:10.1002/pul2.12266

Partially hydrolyzed guar gum suppresses the progression of pulmonary arterial hypertension in a SU5416/hypoxia rat model

Pulm Circ. 2023 Jul 12;13(3):e12266. doi: 10.1002/pul2.12266. eCollection 2023 Jul.

Authors

Takayuki J Sanada^{1

2}, Koji Hosomi¹, Jonguk Park³, Akira Naito², Seiichiro Sakao², Nobuhiro Tanabe^{2

4}, Jun Kunisawa^{1

3

5

6

7

8

9

10

11}, Koichiro Tatsumi², Takuji Suzuki²

Affiliations

¹ Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) National Institutes of Biomedical Innovation, Health, and Nutrition (NIBIOHN) Osaka Japan.
² Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan.
³ Artificial Intelligence Center for Health and Biomedical Research National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) Osaka Japan.
⁴ Department of Respirology Chibaken Saiseikai Narashino Hospital Narashino Japan.
⁵ Graduate School of Pharmaceutical Sciences Osaka University Osaka Japan.
⁶ Graduate School of Medicine Osaka University Osaka Japan.
⁷ Graduate School of Dentistry Osaka University Osaka Japan.
⁸ Graduate School of Science Osaka University Osaka Japan.
⁹ Department of Microbiology and Immunology, Graduate School of Medicine Kobe University Hyogo Japan.
¹⁰ International Vaccine Design Center, Institute of Medical Science University of Tokyo Tokyo Japan.
¹¹ Research Organization for Nano and Life Innovation Waseda University Tokyo Japan.

Abstract

This study investigated the effects of partially hydrolyzed guar gum (PHGG) on the development of pulmonary arterial hypertension using a SU5416/hypoxia rat model. Our results demonstrated that PHGG treatment suppressed the development of pulmonary hypertension and vascular remodeling with an altered gut microbiota composition.

Keywords: Akkermansia; bacteroidetes S27‐7; dietary fiber; gut dysbiosis; prebiotics.