IL17RB expression is associated with malignant cancer behaviors and poor prognosis in oral cancer

Shyng-Shiou F Yuan; Chang-Wei Su; Leong-Perng Chan; Hieu D H Nguyen; Yuk-Kwan Chen; Je-Kang Du; Kuang-Hung Cheng; Yen-Yun Wang

doi:10.1111/odi.14672

IL17RB expression is associated with malignant cancer behaviors and poor prognosis in oral cancer

Oral Dis. 2023 Jul 13. doi: 10.1111/odi.14672. Online ahead of print.

Authors

Shyng-Shiou F Yuan^{1

2

3

4

5

6}, Chang-Wei Su^{5

7

8}, Leong-Perng Chan^{9

10

11}, Hieu D H Nguyen⁷, Yuk-Kwan Chen^{7

12}, Je-Kang Du^{7

13}, Kuang-Hung Cheng^{14

15}, Yen-Yun Wang^{4

5

7}

Affiliations

¹ Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
² Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
³ Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
⁴ Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
⁵ Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁶ Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
⁷ School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁸ Division of Oral and Maxillofacial Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
⁹ Cohort Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
¹⁰ Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
¹¹ Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Municipal Ta-Tung Hospital and Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
¹² Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
¹³ Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
¹⁴ Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
¹⁵ Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.

PMID: 37448179
DOI: 10.1111/odi.14672

Abstract

Objectives: Previously, we demonstrated that IL17RB plays an essential role in lung cancer progression. This study aimed to determine whether IL17RB correlates with oral cancer and promotes oral cancer progression.

Subjects and methods: IL17RB expression in oral cancer tissues and normal tissues was determined by immunohistochemistry staining, while the association of IL17RB expression with the clinicopathological characteristics of oral squamous cell carcinoma (OSCC) patients was analyzed and its correlation with progression-free survival and response to radiotherapy and chemotherapy in OSCC patients was also explored. Western blotting was performed to investigate the expression of IL17RB in various OSCC cell lines; moreover, transwell assay was performed to evaluate the effect of IL17RB expression on cell migration ability.

Results: In this study, we found that IL17RB was expressed higher in OSCC tissues compared to normal oral mucosa tissues and its expression was positively correlated with tumor size, lymph node metastasis, advanced cancer stage, and poor prognosis. In vitro study showed that IL17RB expression in OSCC cell lines as determined by Western blotting, was positively correlated with their migration ability.

Conclusion: Clinical and in vitro studies suggest that IL17RB might serve as an independent risk factor and a therapeutic target for oral cancer.

Keywords: IL17RB; oral cancer; patient survival; therapeutic target.

Abstract

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