Selected Flavonols in Breast and Gynecological Cancer: A Systematic Review

Nutrients. 2023 Jun 28;15(13):2938. doi: 10.3390/nu15132938.

Abstract

The consumption of foods that are rich in phenolic compounds has chemopreventive effects on many cancers, including breast cancer, ovarian cancer, and endometrial cancer. A wide spectrum of their health-promoting properties such as antioxidant, anti-inflammatory, and anticancer activities, has been demonstrated. This paper analyzes the mechanisms of the anticancer action of selected common flavonols, including kemferol, myricetin, quercetin, fisetin, galangin, isorhamnetin, and morin, in preclinical studies, with particular emphasis on in vitro studies in gynecological cancers and breast cancer. In the future, these compounds may find applications in the prevention and treatment of gynecological cancers and breast cancer, but this requires further, more advanced research.

Keywords: breast cancer; flavonols; gynecological tumors.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Antioxidants / pharmacology
  • Breast Neoplasms* / drug therapy
  • Female
  • Flavonoids* / pharmacology
  • Flavonoids* / therapeutic use
  • Flavonols / pharmacology
  • Humans
  • Quercetin / pharmacology

Substances

  • Flavonoids
  • Flavonols
  • Quercetin
  • Antioxidants

Grants and funding

The research received no external funding.