Mouse Models to Examine Differentiated Thyroid Cancer Pathogenesis: Recent Updates

Hye Ryeon Choi; Kwangsoon Kim

doi:10.3390/ijms241311138

Mouse Models to Examine Differentiated Thyroid Cancer Pathogenesis: Recent Updates

Int J Mol Sci. 2023 Jul 6;24(13):11138. doi: 10.3390/ijms241311138.

Authors

Hye Ryeon Choi¹, Kwangsoon Kim²

Affiliations

¹ Department of Surgery, Eulji Medical Center, Eulji University School of Medicine, Seoul 01830, Republic of Korea.
² Department of Surgery, College of Medicine, Catholic University of Korea, Seoul 06591, Republic of Korea.

Abstract

Although the overall prognosis of differentiated thyroid cancer (DTC), the most common endocrine malignancy, is favorable, a subset of patients exhibits aggressive features. Therefore, preclinical models that can be utilized to investigate DTC pathogenesis and novel treatments are necessary. Various mouse models have been developed based on advances in thyroid cancer genetics. This review focuses on recent progress in mouse models that have been developed to elucidate the molecular pathogenesis of DTC.

Keywords: differentiated; follicular; mouse model; papillary; pathogenesis; thyroid cancer.

Publication types

Review

MeSH terms

Adenocarcinoma, Follicular* / pathology
Animals
Disease Models, Animal
Mice
Thyroid Neoplasms* / genetics
Thyroid Neoplasms* / therapy

Grants and funding

This research received no external funding.