Antimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions

Lynn M Pezzanite; Lyndah Chow; Steven W Dow; Laurie R Goodrich; Jessica M Gilbertie; Lauren V Schnabel

doi:10.1016/j.cveq.2023.06.005

Antimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions

Vet Clin North Am Equine Pract. 2023 Dec;39(3):565-578. doi: 10.1016/j.cveq.2023.06.005. Epub 2023 Jul 11.

Authors

Lynn M Pezzanite¹, Lyndah Chow², Steven W Dow³, Laurie R Goodrich², Jessica M Gilbertie⁴, Lauren V Schnabel⁵

Affiliations

¹ Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. Electronic address: lynn.pezzanite@colostate.edu.
² Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
³ Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA; Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
⁴ Department of Microbiology and Immunology, Edward Via College of Osteopathic Medicine, Blacksburg, VA, USA.
⁵ Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA. Electronic address: lvschnab@ncsu.edu.

PMID: 37442729
DOI: 10.1016/j.cveq.2023.06.005

Abstract

Increasing antimicrobial resistance in veterinary practice has driven the investigation of novel therapeutic strategies including regenerative and biologic therapies to treat bacterial infection. Integration of biological approaches such as platelet lysate and mesenchymal stromal cell (MSC) therapy may represent adjunctive treatment strategies for bacterial infections that minimize systemic side effects and local tissue toxicity associated with traditional antibiotics and that are not subject to antibiotic resistance. In this review, we will discuss mechanisms by which biological therapies exert antimicrobial effects, as well as potential applications and challenges in clinical implementation in equine practice.

Keywords: Antimicrobial; Biologic; Horse; Mesenchymal stromal cells; Platelets; Regenerative; Therapies.

Publication types

Review

MeSH terms

Animals
Anti-Bacterial Agents
Blood Platelets
Horse Diseases* / therapy
Horses
Mesenchymal Stem Cells*

Substances

Anti-Bacterial Agents