3D printed membranes of polylactic acid and graphene oxide for guided bone regeneration

Hee Jeong Jang; Moon Sung Kang; Won-Hyeon Kim; Hyo Jung Jo; Sung-Ho Lee; Eun Jeong Hahm; Jung Hyun Oh; Suck Won Hong; Bongju Kim; Dong-Wook Han

doi:10.1039/d3na00112a

3D printed membranes of polylactic acid and graphene oxide for guided bone regeneration

Nanoscale Adv. 2023 Jun 8;5(14):3619-3628. doi: 10.1039/d3na00112a. eCollection 2023 Jul 11.

Authors

Hee Jeong Jang¹, Moon Sung Kang¹, Won-Hyeon Kim², Hyo Jung Jo¹, Sung-Ho Lee^{2

3}, Eun Jeong Hahm^{4

5}, Jung Hyun Oh^{4

5}, Suck Won Hong¹, Bongju Kim², Dong-Wook Han^{1

6}

Affiliations

¹ Department of Cogno-Mechatronics Engineering, Pusan National University Busan 46241 Republic of Korea nanohan@pusan.ac.kr.
² Dental Life Science Research Institute/Innovation Research & Support Center for Dental Science, Seoul National University Dental Hospital Seoul 03080 Republic of Korea bjkim016@gmail.com.
³ Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University Seoul 03080 Republic of Korea.
⁴ Luvantix ADM Co., Ltd Daejeon 34050 Republic of Korea.
⁵ 3DMaterials Co., Ltd Anyang-si Gyeonggi-do 14059 Republic of Korea.
⁶ BIO-IT Fusion Technology Research Institute, Pusan National University Busan 46241 Republic of Korea.

Abstract

We fabricated graphene oxide (GO)-incorporated polylactic acid (PLA) (GO-PLA) films by using three-dimensional (3D) printing to explore their potential benefits as barrier membranes for guided bone regeneration (GBR). Our results showed that the 3D printed GO-PLA films provided highly favorable matrices for preosteoblasts and accelerated new bone formation in rat calvarial bone defect models.