Photoreceptor Ion Channels in Signaling and Disease

Shivangi M Inamdar; Colten K Lankford; Sheila A Baker

doi:10.1007/978-3-031-27681-1_39

Photoreceptor Ion Channels in Signaling and Disease

Adv Exp Med Biol. 2023:1415:269-276. doi: 10.1007/978-3-031-27681-1_39.

Authors

Shivangi M Inamdar¹, Colten K Lankford², Sheila A Baker²

Affiliations

¹ Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA, USA. shivangi-inamdar@uiowa.edu.
² Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA, USA.

PMID: 37440044
DOI: 10.1007/978-3-031-27681-1_39

Abstract

Photoreceptors (PRs) in the neural retina convert photon capture into an electrical signal that is communicated across a chemical synapse to second-order neurons in the retina and on through the rest of the visual pathway. This information is decoded in the visual cortex to create images. The activity of PRs depends on the concerted action of several voltage-gated ion channels that will be discussed in this chapter.

Keywords: CNG; Cav1.4; HCN1; Ion channels; Kv2.1; Kv8.2; Photoreceptors; Retinal degeneration.

MeSH terms

Cyclic Nucleotide-Gated Cation Channels / metabolism
Ion Channels / metabolism
Photoreceptor Cells* / metabolism
Retina* / metabolism
Retinal Cone Photoreceptor Cells / physiology
Signal Transduction
Synapses / metabolism

Substances

Ion Channels
Cyclic Nucleotide-Gated Cation Channels