The design of additives for perovskite-based solar cells seeks to improve the balance between stability and power conversion efficiency. Organic molecules such as theophylline, theobromine and caffeine (xanthines) have proved to be a good engineering solution. As an alternative, we present a first-principles study of the use of organic cations as additives. These cations are obtained when the free nitrogen of the imidazole unit of the aforementioned molecules is quaternized. We have found that the interaction between the organic cations and the MAPbI3 perovskite surface is stronger compared to the organic molecules. The Pb-O and I-H bonds of the interface dominated these interactions. In addition, organic cations showed higher charge transfer through the interface and shallow states that are harmless and could improve the charge carrier mobility. These characteristics show that quaternized xanthines should be a promising additive for perovskite materials in photovoltaic applications.