First report of 6-methylpyridione analogues from Dothiorella sarmentorum, a botryosphaeriaceous fungus associated with grapevine trunk diseases

Nat Prod Res. 2023 Jul 12:1-8. doi: 10.1080/14786419.2023.2232083. Online ahead of print.

Abstract

Dothiorella species are fungal plant pathogens associated with Botryosphaeria dieback of grapevine. Symptoms caused by these fungi on grapevines suggest possible implication of phytotoxic metabolites in the infection mechanisms. However, few studies were conducted to investigate the secondary metabolism of these fungi. In this study, 6-methylpyridione analogues were isolated and identified for the first time in liquid cultures of Dothiorella sarmentorum isolated from symptomatic grapevine in Algeria.

Keywords: Botryosphaeriaceae; Natural products; fungal metabolites; metabolomics.