An activatable endoplasmic reticulum-targeted probe for NIR imaging-guided photothermal therapy

Rui Chen; Rongchen Wang; Jie Sun; Xuemei Dong; Chengjun Dong; Lixin Sun; Xianfeng Gu; Chunchang Zhao

doi:10.1039/d3ob00782k

An activatable endoplasmic reticulum-targeted probe for NIR imaging-guided photothermal therapy

Org Biomol Chem. 2023 Jul 26;21(29):5919-5923. doi: 10.1039/d3ob00782k.

Authors

Rui Chen¹, Rongchen Wang¹, Jie Sun¹, Xuemei Dong¹, Chengjun Dong¹, Lixin Sun¹, Xianfeng Gu², Chunchang Zhao¹

Affiliations

¹ Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200237, P. R. China. zhaocchang@ecust.edu.cn.
² Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China. xfgu@fudan.edu.cn.

PMID: 37435862
DOI: 10.1039/d3ob00782k

Abstract

An H₂O₂-activated, endoplasmic reticulum-targeted theranostic probe was developed. This designed probe could be activated by H₂O₂, resulting in increased NIR fluorescence and photothermal signals, thus achieving specific recognition of H₂O₂ and further photothermal therapy in the endoplasmic reticulum of H₂O₂-overexpressing cancer cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Endoplasmic Reticulum
Humans
Hydrogen Peroxide
Nanoparticles*
Neoplasms*
Phototherapy / methods
Photothermal Therapy
Theranostic Nanomedicine / methods

Substances

Hydrogen Peroxide