Advances in glioma models using in vivo electroporation to highjack neurodevelopmental processes

Longbo Zhang; Angelique Bordey

doi:10.1016/j.bbcan.2023.188951

Advances in glioma models using in vivo electroporation to highjack neurodevelopmental processes

Biochim Biophys Acta Rev Cancer. 2023 Sep;1878(5):188951. doi: 10.1016/j.bbcan.2023.188951. Epub 2023 Jul 9.

Authors

Longbo Zhang¹, Angelique Bordey²

Affiliations

¹ Departments of Neurosurgery, Changde hospital, Xiangya School of Medicine, Central South University, 818 Renmin Street, Wuling District, Changde, Hunan 415003, China; Departments of Neurosurgery, and National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, China; Departments of Neurosurgery, and Cellular & Molecular Physiology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520-8082, USA. Electronic address: zhanglb@csu.edu.cn.
² Departments of Neurosurgery, and Cellular & Molecular Physiology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520-8082, USA.

PMID: 37433417
DOI: 10.1016/j.bbcan.2023.188951

Abstract

Glioma is the most prevalent type of neurological malignancies. Despite decades of efforts in neurosurgery, chemotherapy and radiation therapy, glioma remains one of the most treatment-resistant brain tumors with unfavorable outcomes. Recent progresses in genomic and epigenetic profiling have revealed new concepts of genetic events involved in the etiology of gliomas in humans, meanwhile, revolutionary technologies in gene editing and delivery allows to code these genetic "events" in animals to genetically engineer glioma models. This approach models the initiation and progression of gliomas in a natural microenvironment with an intact immune system and facilitates probing therapeutic strategies. In this review, we focus on recent advances in in vivo electroporation-based glioma modeling and outline the established genetically engineered glioma models (GEGMs).

Keywords: Genetically engineered glioma models (GEGMs); In vivo electroporation; Neurodevelopment; Stem cell.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Brain Neoplasms* / pathology
Electroporation
Genetic Engineering
Glioma* / drug therapy
Humans
Immune System
Tumor Microenvironment

Grants and funding

R01 NS111980/NS/NINDS NIH HHS/United States