Nanomaterial-based ophthalmic drug delivery

Guocheng Xie; Sisi Lin; Feng Wu; Jinyao Liu

doi:10.1016/j.addr.2023.115004

Nanomaterial-based ophthalmic drug delivery

Adv Drug Deliv Rev. 2023 Sep:200:115004. doi: 10.1016/j.addr.2023.115004. Epub 2023 Jul 9.

Authors

Guocheng Xie¹, Sisi Lin¹, Feng Wu², Jinyao Liu³

Affiliations

¹ Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
² Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: wufeng199001@163.com.
³ Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: jyliu@sjtu.edu.cn.

PMID: 37433372
DOI: 10.1016/j.addr.2023.115004

Abstract

The low bioavailability and side effects of conventional drugs for eye disease necessitate the development of efficient drug delivery systems. Accompanying the developments of nanofabrication techniques, nanomaterials have been recognized as promising tools to overcome these challenges due to their flexible and programmable properties. Given the advances achieved in material science, a broad spectrum of functional nanomaterials capable of overcoming various ocular anterior and posterior segment barriers have been explored to satisfy the demands for ocular drug delivery. In this review, we first highlight the unique functions of nanomaterials suitable for carrying and transporting ocular drugs. Then, various functionalization strategies are emphasized to endow nanomaterials with superior performance in enhanced ophthalmic drug delivery. The rational design of several affecting factors is essential for ideal nanomaterial candidates and is depicted as well. Lastly, we introduce the current applications of nanomaterial-based delivery systems in the therapy of different ocular anterior and posterior segment diseases. The limitations of these delivery systems as well as potential solutions are also discussed. This work will inspire innovative design thinking for the development of nanotechnology-mediated strategies for advanced drug delivery and treatment toward ocular diseases.

Keywords: Drug delivery; Nanocarriers; Nanomaterials; Ocular disease; Ophthalmic therapeutics.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Drug Delivery Systems / methods
Eye
Eye Diseases* / drug therapy
Humans
Nanostructures*
Nanotechnology