The Role of Small Interfering RNAs in Hepatocellular Carcinoma

Feng Chen; Wang Zhang; Xinran Gao; Hui Yuan; Kehai Liu

doi:10.1007/s12029-023-00911-w

The Role of Small Interfering RNAs in Hepatocellular Carcinoma

J Gastrointest Cancer. 2023 Jul 11. doi: 10.1007/s12029-023-00911-w. Online ahead of print.

Authors

Feng Chen¹, Wang Zhang¹, Xinran Gao¹, Hui Yuan¹, Kehai Liu²

Affiliations

¹ Department of Biopharmaceutical, Shanghai Ocean University, Shanghai, 201306, China.
² Department of Biopharmaceutical, Shanghai Ocean University, Shanghai, 201306, China. khliu@shou.edu.cn.

PMID: 37432548
DOI: 10.1007/s12029-023-00911-w

Abstract

Background: Hepatocellular carcinoma (HCC), a primary liver cancer with high mortality, is the most common malignant tumor in the world. Currently, the effect of routine treatment is poor, especially for this kind of cancer with strong heterogeneity and late detection. In the past decades, the researches of gene therapy for HCC based on small interfering RNA have blossomed everywhere. This is a promising therapeutic strategy, but the application of siRNA is limited by the discovery of effective molecular targets and the delivery system targeting HCC. As the deepening of research, scientists have developed many effective delivery systems and found more new therapeutic targets.

Conclusions: This paper mainly reviews the research on HCC treatment based on siRNA in recent years, and summarizes and classifies the HCC treatment targets and siRNA delivery systems.

Keywords: Cancer; Gene therapy; Hepatocellular carcinoma; Small interfering RNA.

Publication types

Review