Anodic Dehydrogenative Aromatization of Tetrahydrocarbazoles Leading to Carbazoles

Org Lett. 2023 Jul 21;25(28):5339-5344. doi: 10.1021/acs.orglett.3c01914. Epub 2023 Jul 10.

Abstract

Anodic oxidation-promoted aromatization of 1,2,3,4-tetrahydrocarbazoles was achieved. Nitrogen-protected tetrahydrocarbazoles could be converted to the corresponding carbazoles with the use of bromide as a mediator. LiBr, an inexpensive bromide source, allowed for efficient transformation in the presence of AcOH.