Targeting cyclin D1 as a therapeutic approach for papillary thyroid carcinoma

Wei Cai; Lin-Zhen Shu; Ding-Jie Liu; Lv Zhou; Meng-Meng Wang; Huan Deng

doi:10.3389/fonc.2023.1145082

Targeting cyclin D1 as a therapeutic approach for papillary thyroid carcinoma

Front Oncol. 2023 Jun 22:13:1145082. doi: 10.3389/fonc.2023.1145082. eCollection 2023.

Authors

Wei Cai¹, Lin-Zhen Shu², Ding-Jie Liu³, Lv Zhou¹, Meng-Meng Wang¹, Huan Deng¹

Affiliations

¹ Department of Pathology, The Fourth Affiliated Hospital of Nanchang University, Nanchang, China.
² Medical College, Nanchang University, Nanchang, China.
³ Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, China.

Abstract

Cyclin D1 functions as a mitogenic sensor that specifically binds to CDK4/6, thereby integrating external mitogenic inputs and cell cycle progression. Cyclin D1 interacts with transcription factors and regulates various important cellular processes, including differentiation, proliferation, apoptosis, and DNA repair. Therefore, its dysregulation contributes to carcinogenesis. Cyclin D1 is highly expressed in papillary thyroid carcinoma (PTC). However, the particular cellular mechanisms through which abnormal cyclin D1 expression causes PTC are poorly understood. Unveiling the regulatory mechanisms of cyclin D1 and its function in PTC may help determine clinically effective strategies, and open up better opportunities for further research, leading to the development of novel PTC regimens that are clinically effective. This review explores the mechanisms underlying cyclin D1 overexpression in PTC. Furthermore, we discuss the role of cyclin D1 in PTC tumorigenesis via its interactions with other regulatory elements. Finally, recent progress in the development of therapeutic options targeting cyclin D1 in PTC is examined and summarized.

Keywords: CCND1; cell cycle; cyclin D1; papillary thyroid carcinoma; pathogenesis.

Publication types

Review

Grants and funding

This work was supported by the National Science Foundation of China, No.82160546; the Science Foundation of Jiangxi Province, No. 20202BBG73027; the Foundation of Jiangxi Province for Distinguished Scholars No. JXSQ2023201020.