Deep brain stimulation, lesioning, focused ultrasound: update on utility

Akshay Reddy; Mohammad Reza Hosseini; Aashay Patel; Ramy Sharaf; Vishruth Reddy; Arman Tabarestani; Brandon Lucke-Wold

doi:10.3934/Neuroscience.2023007

Deep brain stimulation, lesioning, focused ultrasound: update on utility

AIMS Neurosci. 2023 Apr 26;10(2):87-108. doi: 10.3934/Neuroscience.2023007. eCollection 2023.

Authors

Akshay Reddy¹, Mohammad Reza Hosseini¹, Aashay Patel¹, Ramy Sharaf¹, Vishruth Reddy², Arman Tabarestani¹, Brandon Lucke-Wold¹

Affiliations

¹ College of Medicine, University of Florida, USA.
² Feinberg School of Medicine, Northwestern University, USA.

Abstract

Procedures for neurological disorders such as Parkinsons Disease (PD), Essential Tremor (ET), Obsessive Compulsive Disorder (OCD), Tourette's Syndrome (TS), and Major Depressive Disorder (MDD) tend to overlap. Common therapeutic procedures include deep brain stimulation (DBS), lesioning, and focused ultrasound (FUS). There has been significant change and innovation regarding targeting mechanisms and new advancements in this field allowing for better clinical outcomes in patients with severe cases of these conditions. In this review, we discuss advancements and recent discoveries regarding these three procedures and how they have led to changes in utilization in certain conditions. We further discuss the advantages and drawbacks of these treatments in certain conditions and the emerging advancements in brain-computer interface (BCI) and its utility as a therapeutic for neurological disorders.

Keywords: deep brain stimulation; focused ultrasound; lesioning.

Publication types

Review