The in vivo and in vitro corrosion behavior of MgO/Mg-Zn-Ca composite with different Zn/Ca ratio

Shuquan Zhang; Chaokun Tang; Jiangtao Feng; Qi Wang; Chenguang Li; Weihao Zhang; Fengxin Zhou; Feng Xue; Baoshan Xu; Shaoyuan Lyu; Minfang Chen; Hao Wang

doi:10.3389/fbioe.2023.1222722

The in vivo and in vitro corrosion behavior of MgO/Mg-Zn-Ca composite with different Zn/Ca ratio

Front Bioeng Biotechnol. 2023 Jun 22:11:1222722. doi: 10.3389/fbioe.2023.1222722. eCollection 2023.

Authors

Shuquan Zhang¹, Chaokun Tang², Jiangtao Feng¹, Qi Wang³, Chenguang Li³, Weihao Zhang³, Fengxin Zhou³, Feng Xue³, Baoshan Xu¹, Shaoyuan Lyu², Minfang Chen^{2

4

5}, Hao Wang¹

Affiliations

¹ Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
² School of Materials Science and Engineering, Tianjin University of Technology, Tianjin, China.
³ Department of Orthopedics, Integrated Chinese and Western Medicine Hospital, Tianjin University, Tianjin, China.
⁴ National Demonstration Center for Experimental Function Materials Education, Tianjin, China.
⁵ Key Laboratory of Display Materials and Photoelectric Device (Ministry of Education), Tianjin, China.

Abstract

The effect of Zn/Ca ratio on the corrosion behavior of Mg-3Zn-0.2Ca-1.0MgO (3ZX) and Mg-1Zn-0.2Ca-1.0MgO (ZX) was investigated on the as-extruded specimens. Microstructure observations revealed that the low Zn/Ca ratio led to the grain growth from 1.6 µm in 3ZX to 8.1 µm in ZX. At the same time, the low Zn/Ca ratio changed the nature of second phase from the existence of Mg-Zn and Ca₂Mg₆Zn₃ phases in 3ZX to the dominated Ca₂Mg₆Zn₃ phase in ZX. The local galvanic corrosion caused by the excessive potential difference was alleviated obviously due to the missing of MgZn phase in ZX. Besides, the in vivo experiment also showed that ZX composite exhibited a good corrosion performance and the bone tissue around the implant grew well.

Keywords: MgO/Mg-Zn-Ca composite; bone growth; in vitro corrosion; in vivo corrosion; second phase corrosion.

Grants and funding

This research was supported by the National Nature Science Foundation of China (grant numbers 52201301 and 52171241) and the Tianjin Nature Science Foundation (grant number 22JCQNJC00750). SZ received a grant from the Tianjin Nature Science Foundation (grant number 21JCYBJC00490). QW received grants from the Science and Technology Planning Project in Tianjin (grant number 21JCQNJC00530) and the Health Science and Technology Project of Tianjin (TJWJ20210N059). Additionally, JF received a grant from the Tianjin Nature Science Foundation (grant number 21JCQNJC01040).