Interobserver reliability of computed tomography angiography in the assessment of ruptured intracranial aneurysm and impact on patient management

Ali H Elmokadem; Basma Abdelmonaem Elged; Ahmed Abdel Razek; Lamiaa Galal El-Serougy; Mohamed Ali Kasem; Mohamed Ali El-Adalany

doi:10.4329/wjr.v15.i6.201

Interobserver reliability of computed tomography angiography in the assessment of ruptured intracranial aneurysm and impact on patient management

World J Radiol. 2023 Jun 28;15(6):201-215. doi: 10.4329/wjr.v15.i6.201.

Authors

Ali H Elmokadem¹, Basma Abdelmonaem Elged², Ahmed Abdel Razek², Lamiaa Galal El-Serougy², Mohamed Ali Kasem³, Mohamed Ali El-Adalany²

Affiliations

¹ Department of Radiology, Mansoura University, Mansoura 35516, Egypt. mokademr83@gmail.com.
² Department of Radiology, Mansoura University, Mansoura 35516, Egypt.
³ Department of Neurosurgery, Mansoura University, Mansoura 35516, Egypt.

Abstract

Background: Aneurysmal subarachnoid hemorrhage is an emergency that can lead to a high mortality rate and many severe complications. It is critical to make a rapid radiological evaluation of ruptured intracranial aneurysms (RIAs) to determine the appropriate surgical treatment.

Aim: To assess the reliability of computed tomography angiography (CTA) in assessing different features of ruptured intracranial aneurysm and its impact on patient management.

Methods: The final cohort of this study consisted of 146 patients with RIAs (75 male and 71 female) who underwent cerebral CTA. Their age ranged from 25 to 80, and the mean age ± SD was 57 ± 8.95 years. Two readers were asked to assess different features related to the aneurysm and perianeurysmal environment. Inter-observer agreement was measured using kappa statistics. Imaging data extracted from non-contrast computed tomography and CTA were considered to categorize the study population into two groups according to the recommended therapeutic approach.

Results: The inter-observer agreement of both reviewers was excellent for the detection of aneurysms (K = 0.95, P = 0.001), aneurysm location (K = 0.98, P = 0.001), and (K = 0.98, P = 0.001), morphology (K = 0.92, P = 0.001) and margins (K = 0.95, P = 0.001). There was an excellent interobserver agreement for the measurement of aneurysm size (K = 0.89, P = 0.001), neck (K = 0.85, P = 0.001), and dome-to-neck ratio (K = 0.98, P = 0.001). There was an excellent inter-observer agreement for the detection of other aneurysm-related features such as thrombosis (K = 0.82, P = 0.001), calcification (K = 1.0, P = 0.001), bony landmark (K = 0.89, P = 0.001) and branch incorporation (K = 0.91, P = 0.001) as well as perianeurysmal findings including vasospasm (K = 0.91, P = 0.001), perianeurysmal cyst (K = 1.0, P = 0.001) and associated vascular lesions (K = 0.83, P = 0.001). Based on imaging features, 87 patients were recommended to have endovascular treatment, while surgery was recommended in 59 patients. 71.2% of the study population underwent the recommended therapy.

Conclusion: CTA is a reproducible promising diagnostic imaging modality for detecting and characterizing cerebral aneurysms.

Keywords: Computed tomography angiography; Intracranial aneurysm; Intracranial hemorrhage; Observer variation; Subarachnoid hemorrhage.