The Genetics of Canine Pulmonary Valve Stenosis

Samantha Kovacs; Brian A Scansen; Joshua A Stern

doi:10.1016/j.cvsm.2023.05.014

The Genetics of Canine Pulmonary Valve Stenosis

Vet Clin North Am Small Anim Pract. 2023 Nov;53(6):1379-1391. doi: 10.1016/j.cvsm.2023.05.014. Epub 2023 Jul 7.

Authors

Samantha Kovacs¹, Brian A Scansen², Joshua A Stern³

Affiliations

¹ Anatomic Pathology Service, School of Veterinary Medicine, University of California Davis, UC Davis VMTH, 1 Garrod Drive, Davis, CA 95616, USA. Electronic address: skovacs@ucdavis.edu.
² College of Veterinary Medicine & Biomedical Sciences, Colorado State University, Veterinary Teaching Hospital, 300 West Drake Road, 1678 Campus Delivery, Fort Collins, CO 80523-1678, USA.
³ Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, UC Davis VMTH, 1 Garrod Drive, Davis, CA 95616, USA.

PMID: 37423844
DOI: 10.1016/j.cvsm.2023.05.014

Abstract

There have been recent advancements in understanding the genetic contribution to pulmonary valve stenosis (PS) in brachycephalic breeds such as the French Bulldog and Bulldog. The associated genes are transcriptions factors involved in cardiac development, which is comparable to the genes that cause PS in humans. However, validation studies and functional follow up is necessary before this information can be used for screening purposes.

Keywords: Bulldog; Congenital heart disease; French Bulldog; Gene; Pulmonic stenosis; RAS/MAPK pathway; Transcription factor.

Publication types

Review

MeSH terms

Animals
Breeding
Craniosynostoses* / veterinary
Dog Diseases* / diagnosis
Dog Diseases* / genetics
Dogs
Humans
Pulmonary Valve Stenosis* / diagnosis
Pulmonary Valve Stenosis* / genetics
Pulmonary Valve Stenosis* / veterinary