The Role of Autoantibodies in Companion Animal Cardiac Disease

Luís Dos Santos; Ashley L Walker

doi:10.1016/j.cvsm.2023.05.018

The Role of Autoantibodies in Companion Animal Cardiac Disease

Vet Clin North Am Small Anim Pract. 2023 Nov;53(6):1367-1377. doi: 10.1016/j.cvsm.2023.05.018. Epub 2023 Jul 7.

Authors

Luís Dos Santos¹, Ashley L Walker²

Affiliations

¹ Department of Veterinary Clinical Sciences, Purdue University, College of Veterinary Medicine, 625 Harrison Street, West Lafayette, IN 47907, USA. Electronic address: dossantos@purdue.edu.
² William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, 1 Garrod Drive, Davis, CA 9561, USA.

PMID: 37423843
DOI: 10.1016/j.cvsm.2023.05.018

Abstract

Clinical studies exploring the role of autoimmune diseases in cardiac dysfunction have become increasingly common in both human and veterinary literature. Autoantibodies (AABs) specific to cardiac receptors have been found in human and canine dilated cardiomyopathy, and circulating autoantibodies have been suggested as a sensitive biomarker for arrhythmogenic right ventricular cardiomyopathy in people and Boxer dogs. In this article, we will summarize recent literature on AABs and their role in cardiac diseases of small animals. Despite the potential for new discoveries in veterinary cardiology, current data in veterinary medicine are limited and further studies are needed.

Keywords: Arrhythmogenic right ventricular cardiomyopathy; Autoimmunity; Canine; Dilated cardiomyopathy; Functional antibodies; Inflammation.

Publication types

Review