Sensitive and simple multi-ion detection using organic nanocrystal enrichment in paper analytical devices

Grasianto; Mao Fukuyama; Motohiro Kasuya; Derrick M Mott; Yoshitaka Koseki; Hitoshi Kasai; Akihide Hibara

doi:10.1016/j.aca.2023.341451

Sensitive and simple multi-ion detection using organic nanocrystal enrichment in paper analytical devices

Anal Chim Acta. 2023 Sep 8:1273:341451. doi: 10.1016/j.aca.2023.341451. Epub 2023 Jun 8.

Authors

Grasianto¹, Mao Fukuyama², Motohiro Kasuya³, Derrick M Mott⁴, Yoshitaka Koseki⁵, Hitoshi Kasai⁶, Akihide Hibara⁷

Affiliations

¹ Department of Chemistry, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember (ITS), Surabaya, 60111, Indonesia.
² Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, 980-8577, Japan; Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, 980-8578, Japan.
³ Faculty of Production Systems Engineering and Sciences, Komatsu University, Ishikawa, 923-8511, Japan.
⁴ Global Learning Center, Tohoku University, Sendai, 980-0862, Japan.
⁵ Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, 980-8577, Japan; Research Institute for Electronic Science, Hokkaido University, Sapporo, 060-0811, Japan.
⁶ Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, 980-8577, Japan.
⁷ Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, 980-8577, Japan; Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, 980-8578, Japan; Department of Chemistry, Tokyo Institute of Technology, Tokyo, Japan. Electronic address: hibara.a.aa@m.titech.ac.jp.

PMID: 37423649
DOI: 10.1016/j.aca.2023.341451

Abstract

Microfluidic paper analytical devices (μPADs) are among the most promising platforms for heavy metal ion analysis. On the other hand, achieving simple and highly sensitive analysis of μPADs is challenging. In this study, we developed a simple enrichment method for sensitive multi-ion detection utilizing water-insoluble organic nanocrystals accumulated on μPAD. By combining the enrichment method with multivariate data analysis, three metal ion concentrations in the ion mixtures were simultaneously quantified with high sensitivity owing to the sensitive responses of the organic nanocrystals. In this work, we successfully quantified Zn²⁺, Cu²⁺, and Ni²⁺ at 20 ng L^-1 in the mixed ion solution using only two dye indicators with a larger sensitivity improvement than those reported in previous studies. Interference studies revealed possibilities for a practical application in real sample analysis. This developed approach also can be used for other analytes.

Keywords: Enrichment; Multi-ion; Multivariate data analysis; Organic nanocrystal; Paper-based device.