Lower Urinary Tract Obstruction in Newborns

Jaime Flores-Torres; Amarilis Sanchez-Valle; Jose R Duncan; Valerie Panzarino; Jessica Marie Rodriguez; Russell S Kirby

doi:10.1016/j.yapd.2023.03.001

Lower Urinary Tract Obstruction in Newborns

Adv Pediatr. 2023 Aug;70(1):131-144. doi: 10.1016/j.yapd.2023.03.001. Epub 2023 May 15.

Authors

Jaime Flores-Torres¹, Amarilis Sanchez-Valle², Jose R Duncan³, Valerie Panzarino⁴, Jessica Marie Rodriguez⁵, Russell S Kirby⁶

Affiliations

¹ Division of Neonatology, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa General Hospital, 5 Tampa General Circle HMT 4th Floor, Suite 450, Tampa, FL 33606, USA. Electronic address: jflorest@usf.edu.
² Division of Genetics and Metabolism, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa General Hospital, 2 Tampa General Circle, Tampa, FL 33606, USA.
³ Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa General Hospital, 2 Tampa General Circle, Tampa, FL 33606, USA.
⁴ Division of Pediatric Nephrology, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa General Hospital, 2 Tampa General Circle, Tampa, FL 33606, USA.
⁵ Division of Pediatric Nephrology, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa General Hospital, Tampa, FL, USA; Johns Hopkins All Children's Hospital, St. Joseph's Hospital, 601 5th Street South, Suite 304,Street, Petersburg, FL 33701, USA.
⁶ Chiles Center, College of Public Health, University of South Florida, 13201 Bruce B Downs Boulevard, MDC56, Tampa, FL 33612, USA.

PMID: 37422291
DOI: 10.1016/j.yapd.2023.03.001

Abstract

Lower urinary tract obstruction (LUTO) is a rare birth defect with a prevalence between 1 in 5,000 and 1 in 25,000 pregnancies. LUTO is one of the most common causes of congenital abnormalities of the renal tract. Several genetic conditions have been associated with LUTO. Most common causes of LUTO are posterior urethral valves and urethral atresia. Despite available prenatal and postnatal treatments, LUTO is a significant cause of morbidity and mortality in newborns causing significant end stage renal disease and pulmonary hypoplasia.

Keywords: End-stage renal disease; Lower urinary tract obstruction; Posterior urethral valves; Prune belly syndrome; Pulmonary hypoplasia; Urethral atresia.

Publication types

Review

MeSH terms

Female
Humans
Infant, Newborn
Kidney
Pregnancy
Retrospective Studies
Ultrasonography, Prenatal
Urethral Obstruction* / diagnosis
Urethral Obstruction* / epidemiology
Urethral Obstruction* / etiology
Urinary Tract* / abnormalities