The mechanisms of minocycline in alleviating ischemic stroke damage and cerebral ischemia-reperfusion injury

Kemeng Zhao; Pengwei Wang; Xiaoguang Tang; Na Chang; Haonan Shi; Longfei Guo; Bingyi Wang; Pengfei Yang; Tiantian Zhu; Xinghua Zhao

doi:10.1016/j.ejphar.2023.175903

The mechanisms of minocycline in alleviating ischemic stroke damage and cerebral ischemia-reperfusion injury

Eur J Pharmacol. 2023 Sep 15:955:175903. doi: 10.1016/j.ejphar.2023.175903. Epub 2023 Jul 6.

Authors

Kemeng Zhao¹, Pengwei Wang², Xiaoguang Tang³, Na Chang³, Haonan Shi⁴, Longfei Guo³, Bingyi Wang³, Pengfei Yang⁵, Tiantian Zhu⁶, Xinghua Zhao⁷

Affiliations

¹ Basic Medical College, Xinxiang Medical University, Xinxiang, China; College of First Clinical, Xinxiang Medical University, Xinxiang, China.
² Department of Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, 453100, Henan, China.
³ College of Pharamacy, Xinxiang Medical University, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang, China.
⁴ Sanquan Medical College, Xinxiang Medical University, Xinxiang, China.
⁵ College of Pharamacy, Xinxiang Medical University, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang, China. Electronic address: 171048@xxmu.edu.cn.
⁶ College of Pharamacy, Xinxiang Medical University, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang, China. Electronic address: zhutt@xxmu.edu.cn.
⁷ Basic Medical College, Xinxiang Medical University, Xinxiang, China. Electronic address: zphx1985@163.com.

PMID: 37422120
DOI: 10.1016/j.ejphar.2023.175903

Abstract

Stroke is a group of diseases resulting from cerebral vascular rupture or obstruction and subsequent brain blood circulation disorder, leading to rapid neurological deficits. Ischemic stroke accounts for the majority of all stroke cases. The current treatments for ischemic stroke mainly include t-PA thrombolytic therapy and surgical thrombectomy. However, these interventions aimed at recanalizing cerebral vessels can paradoxically lead to ischemia-reperfusion injury, which exacerbates the severity of brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has been shown to possess a wide range of neuroprotective effects independent of its antibacterial activity. Here we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury based on the pathogenesis of cerebral ischemia-reperfusion injury, including its modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death and blood-brain barrier injury, and also introduce the role of minocycline in alleviating stroke-related complications, in order to provide a theoretical basis for the clinical application of minocycline in cerebral ischemia-reperfusion injury.

Keywords: Cerebral ischemia; Cerebral ischemia-reperfusion injury; Minocycline; Neuroprotection; Stroke.

Publication types

Review