Efficient Synthesis of a Schiff Base Copper(II) Complex Using a Microfluidic Device

Masashi Kobayashi; Takashiro Akitsu; Masahiro Furuya; Tetsushi Sekiguchi; Shuichi Shoji; Takashi Tanii; Daiki Tanaka

doi:10.3390/mi14040890

Efficient Synthesis of a Schiff Base Copper(II) Complex Using a Microfluidic Device

Micromachines (Basel). 2023 Apr 21;14(4):890. doi: 10.3390/mi14040890.

Authors

Masashi Kobayashi¹, Takashiro Akitsu², Masahiro Furuya³, Tetsushi Sekiguchi⁴, Shuichi Shoji¹, Takashi Tanii¹, Daiki Tanaka⁴

Affiliations

¹ Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
² Department of Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
³ Cooperative Major in Nuclear Energy, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1, Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
⁴ Research Organization for Nano & Life Innovation, Waseda University, 513 Tsurumakicho, Shinjuku-ku, Tokyo 162-0041, Japan.

Abstract

The efficient synthesis of amino acid Schiff base copper(II) complexes using a microfluidic device was successfully achieved. Schiff bases and their complexes are remarkable compounds due to their high biological activity and catalytic function. Conventionally, products are synthesized under reaction conditions of 40 °C for 4 h using a beaker-based method. However, in this paper, we propose using a microfluidic channel to enable quasi-instantaneous synthesis at room temperature (23 °C). The products were characterized using UV-Vis, FT-IR, and MS spectroscopy. The efficient generation of compounds using microfluidic channels has the potential to significantly contribute to the efficiency of drug discovery and material development due to high reactivity.

Keywords: Schiff base; copper complex; high throughput; microfluidic.

Abstract

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