MicroRNA electrochemical biosensors for pancreatic cancer

Fereshteh Rahdan; Fateme Bina; Elham Norouz Dolatabadi; Donya Shaterabadi; Seyyed Hossein Khatami; Yousof Karami; Nafiseh Dorosti; Mortaza Taheri-Anganeh; Peyman Asadi; Rahmatollah Soltani; Mohammad Reza Pashaei; Ahmad Movahedpour

doi:10.1016/j.cca.2023.117472

MicroRNA electrochemical biosensors for pancreatic cancer

Clin Chim Acta. 2023 Aug 1:548:117472. doi: 10.1016/j.cca.2023.117472. Epub 2023 Jul 5.

Affiliations

¹ Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
² Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Department of Clinical Science, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
⁵ Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁶ Cellular and Molecular Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
⁷ Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
⁸ Clinical Education Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
⁹ Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
¹⁰ Behbahan Faculty of Medical Sciences, Behbahan, Iran. Electronic address: ahmad.movaed14@gmail.com.

PMID: 37419303
DOI: 10.1016/j.cca.2023.117472

Abstract

Pancreatic cancer (PC) is one of the deadliest cancers worldwide. MicroRNAs (miRs) are sensitive molecular diagnostic tools that can serve as highly accurate biomarkers in many disease states in general and cancer specifically. MiR-based electrochemical biosensors can be easily and inexpensively manufactured, making them suitable for clinical use and mass production for point-of-care use. This paper reviews nanomaterial-enhanced miR-based electrochemical biosensors in pancreatic cancer detection, analyzing both labeled and label-free approaches, as well as enzyme-based and enzyme-free methods.

Keywords: Biosensor; Diagnosis; MicroRNA; Pancreatic cancer.

Publication types

Review

MeSH terms

Biosensing Techniques* / methods
Electrochemical Techniques / methods
Humans
MicroRNAs* / genetics
Nanostructures*
Pancreatic Neoplasms* / diagnosis
Pancreatic Neoplasms* / genetics

Substances

MicroRNAs