Context matters: hPSC-derived microglia thrive in a humanized brain environment in vivo

Jonas Cerneckis; Yanhong Shi

doi:10.1016/j.stem.2023.05.013

Context matters: hPSC-derived microglia thrive in a humanized brain environment in vivo

Cell Stem Cell. 2023 Jul 6;30(7):909-910. doi: 10.1016/j.stem.2023.05.013.

Authors

Jonas Cerneckis¹, Yanhong Shi²

Affiliations

¹ Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd, Duarte, CA 91010, USA.
² Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd, Duarte, CA 91010, USA. Electronic address: yshi@coh.org.

Abstract

It remains challenging to create a physiologically relevant human-brain-like environment that would support maturation of human pluripotent stem cell (hPSC)-derived microglia (hMGs). Schafer et al.¹ (Cell, 2023) now develop an in vivo neuroimmune organoid model with mature homeostatic hMGs for the study of brain development and disease.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Brain
Cell Differentiation
Humans
Microglia*
Pluripotent Stem Cells* / physiology

Abstract

Publication types

MeSH terms

Grants and funding