Evolutionary Dynamics and Intermittent Therapy for Metastatic Cancers

J Clin Oncol. 2023 Oct 1;41(28):4469-4471. doi: 10.1200/JCO.23.00647. Epub 2023 Jul 7.

Authors

Jad Chahoud¹, Alexander R A Anderson², Jingsong Zhang¹, Joel Brown², Robert A Gatenby^{2

3}

Affiliations

¹ Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL.
² Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center, Tampa, FL.
³ Department of Radiology, Department of Integrated Mathematical Oncology H. Lee Moffitt Cancer Center, Tampa, FL.

PMID: 37418680
PMCID: PMC10553063 (available on 2024-10-01)
DOI: 10.1200/JCO.23.00647

Abstract

Mathematical models show that the induction period of intermittent cancer therapy drives cancer toward resistance

MeSH terms

Antineoplastic Agents, Hormonal
Humans
Neoplasms* / drug therapy
Neoplasms, Second Primary*

Substances

Antineoplastic Agents, Hormonal

Grants and funding