Lymph node metastasis: An immunological burden

J Exp Med. 2023 Sep 4;220(9):e20230904. doi: 10.1084/jem.20230904. Epub 2023 Jul 7.

Abstract

Lymph node metastasis in breast cancer depends in part on the acquisition of an IFN-dependent, MHC-II+ state that induces regulatory T cell expansion and local immune suppression (Lei et al. 2023. J. Exp. Med.https://doi.org/10.1084/jem.20221847).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Breast Neoplasms* / immunology
  • Breast Neoplasms* / pathology
  • Humans
  • Lymphatic Metastasis* / immunology
  • T-Lymphocytes, Regulatory