Mechanism of fibroblast growth factor 21 in cardiac remodeling

Zeyu Zhao; Xuemei Cui; Zhangping Liao

doi:10.3389/fcvm.2023.1202730

Mechanism of fibroblast growth factor 21 in cardiac remodeling

Front Cardiovasc Med. 2023 Jun 21:10:1202730. doi: 10.3389/fcvm.2023.1202730. eCollection 2023.

Authors

Zeyu Zhao¹, Xuemei Cui², Zhangping Liao³

Affiliations

¹ Queen Mary College, Nanchang University, Nanchang, China.
² Fourth Clinical Medical College, Nanchang University, Nanchang, China.
³ Jiangxi Provincial Key Laboratory of Basic Pharmacology School of Pharmaceutical Science, Nanchang University, Nanchang, China.

Abstract

Cardiac remodeling is a basic pathological process that enables the progression of multiple cardiac diseases to heart failure. Fibroblast growth factor 21 is considered a regulator in maintaining energy homeostasis and shows a positive role in preventing damage caused by cardiac diseases. This review mainly summarizes the effects and related mechanisms of fibroblast growth factor 21 on pathological processes associated with cardiac remodeling, based on a variety of cells of myocardial tissue. The possibility of Fibroblast growth factor 21 as a promising treatment for the cardiac remodeling process will also be discussed.

Keywords: autophagy; energy metabolism; fibroblast growth factor 21 (FGF21); heart remodeling; inflammation; oxidation.

Publication types

Review