Different exercise training intensities prevent type 2 diabetes mellitus-induced myocardial injury in male mice

Zuowei Pei; Rui Zhou; Wei Yao; Shuang Dong; Yingshu Liu; Zhengnan Gao

doi:10.1016/j.isci.2023.107080

Different exercise training intensities prevent type 2 diabetes mellitus-induced myocardial injury in male mice

iScience. 2023 Jun 15;26(7):107080. doi: 10.1016/j.isci.2023.107080. eCollection 2023 Jul 21.

Authors

Zuowei Pei^{1

2}, Rui Zhou³, Wei Yao³, Shuang Dong¹, Yingshu Liu⁴, Zhengnan Gao⁴

Affiliations

¹ Department of Cardiology, Central Hospital of Dalian University of Technology, Dalian, China.
² Department of Central Laboratory, Central Hospital of Dalian University of Technology, Dalian, China.
³ Department of Internal Medicine, Affiliated Zhong Shan Hospital of Dalian University, Dalian, China.
⁴ Department of Endocrinology, Central Hospital of Dalian University of Technology, Dalian, China.

Abstract

Type 2 diabetes mellitus (T2DM) usually develop myocardial injury and that exercise may have a positive effect on cardiac function. However, the effect of exercise intensity on cardiac function has not yet been fully examined. This study aimed to explore different exercise intensities on T2DM-induced myocardial injury. 18-week-old male mice were randomly divided into four groups: a control group, the T2DM, T2DM + medium-intensity continuous training (T2DM + MICT), and T2DM + high-intensity interval training (T2DM + HIIT) groups. In the experimental group, mice were given high-fat foods and streptozotocin for six weeks and then divided into two exercise training groups, in which mice were subjected to exercise five days per week for 24 consecutive weeks. Finally, metabolic characteristics, cardiac function, myocardial remodeling, myocardial fibrosis, oxidative stress, and apoptosis were analyzed. HIIT treatment improved cardiac function and improved myocardial injury. In conclusion, HIIT may be an effective means to guard against T2DM-induced myocardial injury.

Keywords: Cardiovascular medicine; Human metabolism; Kinesiology.