Dissemination and genome characterization of a human adenovirus F41 in a patient with B-Cell lymphoma

Amary Fall; Victoria L Campodónico; Craig Howard; Nicholas Gallagher; Gabrielle Bailey; Adriana E Kajon; Heba H Mostafa

doi:10.1186/s12985-023-02101-3

Dissemination and genome characterization of a human adenovirus F41 in a patient with B-Cell lymphoma

Virol J. 2023 Jul 6;20(1):141. doi: 10.1186/s12985-023-02101-3.

Authors

Amary Fall^#¹, Victoria L Campodónico^#¹, Craig Howard², Nicholas Gallagher¹, Gabrielle Bailey¹, Adriana E Kajon³, Heba H Mostafa⁴

Affiliations

¹ Hopkins Medicine, Department of Pathology, Medical Microbiology, Baltimore, MD, USA.
² Department of Pathology, Medical Microbiology, Johns Hopkins Hospital, Baltimore, MD, USA.
³ Lovelace Biomedical Research Institute, Albuquerque, NM, USA.
⁴ Hopkins Medicine, Department of Pathology, Medical Microbiology, Baltimore, MD, USA. hmostaf2@jhmi.edu.

^# Contributed equally.

Abstract

Adenovirus (HAdV) F41 is a common cause of gastroenteritis and has rarely been reported associated with disseminated disease. In this report, an adult patient with a history of ulcerative colitis, cryptogenic cirrhosis, stage III adenocarcinoma, high-grade diffuse large B-cell lymphoma on chemotherapy was diagnosed with disseminated adenovirus infection. HAdV DNA was quantified in stool, plasma, and urine with viral loads of 7, 4, and 3 log10 copies/mL, respectively. The patient's course was rapidly progressive and he passed away 2 days after initiation of antiviral therapy. The patient's infecting virus was characterized as HAdV-F41 by whole genome sequencing.

Keywords: Adenovirus F41; B-cell lymphoma; Dissemination; Genome characterization.

MeSH terms

Adenoviridae / genetics
Adenoviridae Infections*
Adenovirus Infections, Human*
Adenoviruses, Human* / genetics
Adult
Humans
Lymphoma, B-Cell* / complications
Male

Supplementary concepts

Human mastadenovirus F