Mechanisms of hypoxaemia in severe pulmonary hypertension associated with COPD

Eur Respir J. 2023 Jul 20;62(1):2300463. doi: 10.1183/13993003.00463-2023. Print 2023 Jul.

Abstract

Severe hypoxaemia, characteristic of COPD with severe pulmonary hypertension, is due to a combination of greater ventilation–perfusion mismatch, increased intrapulmonary shunt and reduced PvO2, with negligible hypoxic pulmonary vasoconstriction regulation https://bit.ly/3Wnzpik

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Hypertension, Pulmonary* / complications
  • Hypoxia / complications
  • Oxygen
  • Pulmonary Disease, Chronic Obstructive* / complications
  • Respiration Disorders* / complications

Substances

  • Oxygen