Retrospective analysis on incidence and risk factors for early acute renal injury after lung transplantation

Sen Lu; Weiwei Huang; Hongli He; Xiaobo Huang; Jiajin Li; Yu Lei; Gang Feng; Wei Xu; Xiaoqin Zhang

doi:10.1016/j.trim.2023.101889

Retrospective analysis on incidence and risk factors for early acute renal injury after lung transplantation

Transpl Immunol. 2023 Oct:80:101889. doi: 10.1016/j.trim.2023.101889. Epub 2023 Jul 4.

Authors

Sen Lu¹, Weiwei Huang², Hongli He¹, Xiaobo Huang¹, Jiajin Li³, Yu Lei¹, Gang Feng⁴, Wei Xu⁵, Xiaoqin Zhang⁶

Affiliations

¹ Department of ICU, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.
² Department of Critical Care Medicine, Chengdu Second People's Hospital, Chengdu 610072, China.
³ Department of Critical Care Medicine, Mianyang People's Hospital, Mianyang 621053, China.
⁴ Department of Thoracic Surgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.
⁵ Department of Critical Care Medicine, Chengdu Seventh People's Hospital, Chengdu 610072, China. Electronic address: 1281751695@qq.com.
⁶ Department of ICU, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China. Electronic address: lscool1987@163.com.

PMID: 37414263
DOI: 10.1016/j.trim.2023.101889

Abstract

Background: Acute renal injury (AKI) is a common complication of lung transplantation. However, there has been no related research on whether the relationship between fluid balance and input and output influences the occurrence of early AKI. This study aimed to explore the relationship between early fluid balance and input and output on the incidence of early AKI after lung transplantation.

Methods: Data from 31 patients who underwent lung transplantation in the Department of Intensive Care Medicine of the Sichuan Academy of Medical Sciences, Sichuan People's Hospital, from August 2018 to July 2021 were collected. To summarize the occurrence of early AKI after lung transplantation, The main indicators of lung transplantation patients were collected. The risk factors for early AKI after lung transplantation were analyzed.

Results: Among the 31 patients who underwent lung transplantation, 21 had early postoperative AKI, with an incidence rate of 67.7%. Compared with the non-AKI group, the hospitalization and ICU hospitalization times of the AKI group were longer (P < 0.05). Multivariate regression analysis showed that intraoperative input volume, BMI, and fluid balance on the first day after lung transplantation were independent risk factors for AKI.

Conclusion: Intraoperative input volume, BMI, and fluid balance on the first day after lung transplantation were independent risk factors for AKI.

Keywords: Acute kidney injury (AKI); Fluid balance; Lung transplantation; Risk factors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acute Kidney Injury* / epidemiology
Acute Kidney Injury* / etiology
Humans
Incidence
Lung Transplantation* / adverse effects
Postoperative Complications / epidemiology
Retrospective Studies
Risk Factors