Association of cardiovascular health using Life's Essential 8 with noncommunicable disease multimorbidity

Yuan Zhang; Mengzi Sun; Yanfang Wang; Tong Xu; Ning Ning; Li Tong; Yue He; Lina Jin; Yanan Ma

doi:10.1016/j.ypmed.2023.107607

Association of cardiovascular health using Life's Essential 8 with noncommunicable disease multimorbidity

Prev Med. 2023 Sep:174:107607. doi: 10.1016/j.ypmed.2023.107607. Epub 2023 Jul 4.

Authors

Yuan Zhang¹, Mengzi Sun², Yanfang Wang³, Tong Xu⁴, Ning Ning⁵, Li Tong⁶, Yue He⁷, Lina Jin⁸, Yanan Ma⁹

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: yuanzhang21@mails.jlu.edu.cn.
² Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: smz20@mails.jlu.edu.cn.
³ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: yanfang21@mails.jlu.edu.cn.
⁴ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: tongxu22@mails.jlu.edu.cn.
⁵ Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, Liaoning, Shenyang, China. Electronic address: 2022120255@cmu.edu.cn.
⁶ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: tongli20@mails.jlu.edu.cn.
⁷ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: heyue21@mails.jlu.edu.cn.
⁸ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China. Electronic address: jinln@jlu.edu.cn.
⁹ Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, Liaoning, Shenyang, China. Electronic address: ynma@cmu.edu.cn.

PMID: 37414227
DOI: 10.1016/j.ypmed.2023.107607

Abstract

Cardiovascular health (CVH) is closely associated with various noncommunicable diseases (NCDs) and comorbidity; however, the influence of CVH on NCD multimorbidity was not fully elucidated. We aimed to examine the association between CVH using Life's Essential 8 (LE8) and NCD multimorbidity among adults, males, and females in the United States, conducting a cross-sectional analysis using data involving 24,445 participants from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. LE8 was categorized into low, moderate, and high CVH groups. Multivariate logistic regressions and restricted cubic spline regressions were used to estimate the association between LE8 and NCD multimorbidity. Overall, 6162 participants had NCD multimorbidity, of which 1168 (43.5%), 4343 (25.9%), and 651 (13.4%) had low, moderate, and high CVH, separately. After multivariable adjustment, LE8 was negatively associated with NCD multimorbidity among adults (odds ratio (OR) for per 1 standard deviation (SD) increase in LE8 and 95% confidence interval (CI), 0.67 (0.64, 0.69)), and the top 3 NCDs associated with CVH were emphysema, congestive heart failure, stroke, and the dose-response relationships between LE8 and NCD multimorbidity were observed among adults (overall P < 0.001). Similar patterns were also identified among males and females. Higher CVH measured by the LE8 score was associated with lower odds of NCD multimorbidity among adults, males, and females.

Keywords: Adults; Cardiovascular health; Life's Essential 8; Multimorbidity; NHANES; Noncommunicable disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cardiovascular Diseases* / epidemiology
Comorbidity
Cross-Sectional Studies
Female
Humans
Male
Noncommunicable Diseases* / epidemiology
Nutrition Surveys
Risk Factors
United States / epidemiology