Emerging nanotechnology for Alzheimer's disease: From detection to treatment

Nan Song; Si Sun; Ke Chen; Yang Wang; Hao Wang; Jian Meng; Meili Guo; Xiao-Dong Zhang; Ruiping Zhang

doi:10.1016/j.jconrel.2023.07.004

Emerging nanotechnology for Alzheimer's disease: From detection to treatment

J Control Release. 2023 Aug:360:392-417. doi: 10.1016/j.jconrel.2023.07.004. Epub 2023 Jul 10.

Authors

Nan Song¹, Si Sun², Ke Chen³, Yang Wang³, Hao Wang³, Jian Meng⁴, Meili Guo⁵, Xiao-Dong Zhang⁶, Ruiping Zhang⁷

Affiliations

¹ Department of Physics, School of Science, Tianjin Chengjian University, Tianjin 300384, China.
² Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin 300350, China.
³ Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China.
⁴ The First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.
⁵ Department of Physics, School of Science, Tianjin Chengjian University, Tianjin 300384, China. Electronic address: meiliguo314@163.com.
⁶ Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin 300350, China; Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China. Electronic address: xiaodongzhang@tju.edu.cn.
⁷ The First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China. Electronic address: zrp_7142@sxmu.edu.cn.

PMID: 37414222
DOI: 10.1016/j.jconrel.2023.07.004

Abstract

Alzheimer's disease (AD), one of the most common chronic neurodegenerative diseases, is characterized by memory impairment, synaptic dysfunction, and character mutations. The pathological features of AD are Aβ accumulation, tau protein enrichment, oxidative stress, and immune inflammation. Since the pathogenesis of AD is complicated and ambiguous, it is still challenging to achieve early detection and timely treatment of AD. Due to the unique physical, electrical, magnetic, and optical properties of nanoparticles (NPs), nanotechnology has shown great potential for detecting and treating AD. This review provides an overview of the latest developments in AD detection via nanotechnology based on NPs with electrochemical sensing, optical sensing, and imaging techniques. Meanwhile, we highlight the important advances in nanotechnology-based AD treatment through targeting disease biomarkers, stem-cell therapy and immunotherapy. Furthermore, we summarize the current challenges and present a promising prospect for nanotechnology-based AD diagnosis and intervention.

Keywords: Alzheimer's disease; Biomarkers; Detection; Nanoparticles; Treatment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease* / diagnosis
Alzheimer Disease* / metabolism
Alzheimer Disease* / therapy
Amyloid beta-Peptides / metabolism
Humans
Nanoparticles* / therapeutic use
Nanotechnology
Oxidative Stress

Substances

Amyloid beta-Peptides