Recent advances in regulating lipid metabolism to prevent coronary heart disease

Chem Phys Lipids. 2023 Sep:255:105325. doi: 10.1016/j.chemphyslip.2023.105325. Epub 2023 Jul 4.

Abstract

The pathogenesis of coronary heart disease is a highly complex process, with lipid metabolism disorders being closely linked to its development. Therefore, this paper analyzes the various factors that influence lipid metabolism, including obesity, genes, intestinal microflora, and ferroptosis, through a comprehensive review of basic and clinical studies. Additionally, this paper delves deeply into the pathways and patterns of coronary heart disease. Based on these findings, it proposes various intervention pathways and therapeutic methods, such as the regulation of lipoprotein enzymes, lipid metabolites, and lipoprotein regulatory factors, as well as the modulation of intestinal microflora and the inhibition of ferroptosis. Ultimately, this paper aims to offer new ideas for the prevention and treatment of coronary heart disease.

Keywords: Atherosclerosis; Coronary heart disease; Influencing factors; Lipid metabolism; Preventive treatment.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coronary Disease* / etiology
  • Coronary Disease* / metabolism
  • Coronary Disease* / prevention & control
  • Humans
  • Lipid Metabolism*
  • Lipoproteins / metabolism
  • Obesity

Substances

  • Lipoproteins