Silver-Catalyzed Chlorocyclization for the Synthesis of 3-Chloro-2 H-chromenes

Yunhao Tang; Weidong Pan; Yuzhu Yang

doi:10.1021/acs.joc.2c02864

Silver-Catalyzed Chlorocyclization for the Synthesis of 3-Chloro-2 H-chromenes

J Org Chem. 2023 Jul 21;88(14):9668-9676. doi: 10.1021/acs.joc.2c02864. Epub 2023 Jul 6.

Authors

Yunhao Tang^{1

2

3}, Weidong Pan^{1

2

3}, Yuzhu Yang^{1

2}

Affiliations

¹ State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Gaohai Road, Guiyang 550014, P. R. China.
² The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, 3491 Baijin Road, Guiyang 550014, P. R. China.
³ School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, P. R. China.

PMID: 37410887
DOI: 10.1021/acs.joc.2c02864

Abstract

A silver-catalyzed chlorocyclization reaction of aryl 3-aryl-2-propyn-1-yl ethers in the presence of NCS under darkness was accomplished, which provides a straightforward and efficient access to 3-chloro-2H-chromenes.