Intermediate-Term Outcomes Following Transcatheter Aortic Valve Implantation in Patients with a History of Chest Radiation Therapy: A Propensity Score Matched Analysis

Kris Kumar; Mohammed Osman; Ashraf Samhan; Craig C Morris; Trisha Chau; Tessa Herman; Gurion Lantz; Scott M Chadderdon; Howard K Song; Firas E Zahr; Harsh Golwala

Intermediate-Term Outcomes Following Transcatheter Aortic Valve Implantation in Patients with a History of Chest Radiation Therapy: A Propensity Score Matched Analysis

J Invasive Cardiol. 2023 Jun;35(6):E291-E293.

Authors

Kris Kumar, Mohammed Osman, Ashraf Samhan, Craig C Morris, Trisha Chau, Tessa Herman, Gurion Lantz, Scott M Chadderdon, Howard K Song, Firas E Zahr, Harsh Golwala¹

Affiliation

¹ Knight Cardiovascular Institute, Oregon Health & Science University, UHN-62, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239. golwala@ohsu.edu.

PMID: 37410745

Abstract

Chest radiation therapy (XRT) has been associated with a higher rate of mortality following surgical aortic valve replacement. We performed a single-center retrospective analysis of patients with severe AS who underwent TAVI from January 1 2012 to July 31 2020 comparing patients with and without XRT. A total of 915 patients met inclusion criteria, with a total of 50 patients found to have a history of XRT. At a mean follow-up of 2.4 years, unadjusted and propensity score matching analysis demonstrated no differences in mortality, heart failure or bleeding-related hospitalization, overall stroke, and 30-day pacemaker implantation in patients with and without XRT.

Keywords: outcomes; transcatheter aortic valve implantation; aortic stenosis; radiation therapy.

MeSH terms

Aortic Valve / diagnostic imaging
Aortic Valve / surgery
Aortic Valve Stenosis* / diagnosis
Aortic Valve Stenosis* / surgery
Heart Valve Prosthesis Implantation*
Humans
Propensity Score
Retrospective Studies
Risk Factors
Transcatheter Aortic Valve Replacement* / adverse effects
Treatment Outcome