Perspective: Mass Spectrometry Imaging - The Next 5 Years

Malcolm R Clench; Laura M Cole

doi:10.1007/978-1-0716-3319-9_17

Perspective: Mass Spectrometry Imaging - The Next 5 Years

Methods Mol Biol. 2023:2688:203-210. doi: 10.1007/978-1-0716-3319-9_17.

Authors

Malcolm R Clench¹, Laura M Cole²

Affiliations

¹ Centre for Mass Spectrometry Imaging, Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK. m.r.clench@shu.ac.uk.
² Centre for Mass Spectrometry Imaging, Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK.

PMID: 37410295
DOI: 10.1007/978-1-0716-3319-9_17

Abstract

In order to achieve even more widespread adoption over the next 5 years, a number of issues in mass spectrometry imaging need to be addressed. These are non-observation of compounds (due to ionization suppression), sample throughput, imaging of low-abundant species, and how to extract information from the large volumes of data generated. In this article, how current research indicates that these issues will be resolved along with potential application areas that MSI could look to exploit is discussed.

Keywords: 3D tissue models; Artificial intelligence; MALDI-2; MALDI-IHC; Mass resolution; Plasma post-ionization; Sub-ppm; n-DESI.

MeSH terms

Diagnostic Imaging*
Spectrometry, Mass, Electrospray Ionization* / methods
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods