Results of open bleb revision as management of primary bleb failure following XEN 45 gel stent and Preserflo™ Microshunt

Theresa Theilig; Menelaos Papadimitriou; Ghaith Albaba; Daniel Meller; Somar M Hasan

doi:10.1007/s00417-023-06152-8

Results of open bleb revision as management of primary bleb failure following XEN 45 gel stent and Preserflo™ Microshunt

Graefes Arch Clin Exp Ophthalmol. 2023 Nov;261(11):3249-3255. doi: 10.1007/s00417-023-06152-8. Epub 2023 Jul 6.

Authors

Theresa Theilig¹, Menelaos Papadimitriou², Ghaith Albaba², Daniel Meller², Somar M Hasan²

Affiliations

¹ Klinik für Augenheilkunde, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany. Theresa.Theilig@med.uni-jena.de.
² Klinik für Augenheilkunde, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.

Abstract

Purpose: The success of filtering surgery as in XEN-Gel-Stent (XEN) and Preserflo-Microshunt (PF) depends mainly on a functioning bleb. Primary bleb failure (PBF) is not uncommon and can be treated with needling or open bleb revision (OBR). The aim of the study is to compare surgical outcomes of OBR after XEN and PF.

Methods: Eyes which received OBR as management of PBF following implantation of XEN or PF were retrospectively included. Intraocular pressure (IOP), number of IOP lowering medications (NoM), and success rates (SR) were compared between groups. Complete and qualified success were defined as IOP ≤18mmHg and a reduction of >20%, without and with medications, respectively.

Results: 29 eyes after XEN and 23 eyes after PF were included. Six months following OBR, IOP reduced from 24.2±4.7 to 13.5±4.6 after XEN and from 27.3±8.7 to 15.9±5.8mmHg after PF (both p<0.001). NoM did not change (0.7±1.3 to 0.4±0.8 after XEN and 1.2±1.3 to 1.0±1.5 after PF, p>0.05 for both). Complete SR were higher after XEN than after PF (58.6% vs. 30.4%, p=0.04). Complications were mild and managed mainly conservatively. Additional glaucoma surgery was needed in 17% and 30% of eyes after XEN and PF, respectively (p=0.26).

Conclusion: Although OBR was effective as management of PBF following XEN and PF, SR were higher after XEN than after PF along with comparable safety profile. The change of the surgical approach from ab interno during XEN-Implantation to ab externo during OBR seems to enhance SR compared to PF, where both interventions are done ab externo.

Keywords: Bleb revision; Filtering glaucoma surgery; MIGS; Preserflo; XEN.