Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults

Rodrigo Guarischi-Sousa; Elias Salfati; Pik Fang Kho; Kruthika R Iyer; Austin T Hilliard; David M Herrington; Philip S Tsao; Shoa L Clarke; Themistocles L Assimes

doi:10.1161/CIRCGEN.122.004047

Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults

Circ Genom Precis Med. 2023 Oct;16(5):480-482. doi: 10.1161/CIRCGEN.122.004047. Epub 2023 Jul 6.

Authors

Rodrigo Guarischi-Sousa¹, Elias Salfati², Pik Fang Kho¹, Kruthika R Iyer¹, Austin T Hilliard³, David M Herrington⁴, Philip S Tsao^{1

5

3}, Shoa L Clarke^#^{1

6

3}, Themistocles L Assimes^#^{1

7

5

3}

Affiliations

¹ Department of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.).
² Scripps Research Translational Institute at Scripps Research, La Jolla, CA (E.S.).
³ VA Palo Alto Health Care System, CA (A.T.H., P.S.T., S.L.C., T.L.A.).
⁴ Department of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.).
⁵ Cardiovascular Institute (P.S.T., T.L.A.).
⁶ Department of Pediatrics, Division of Pediatric Cardiology, Stanford University School of Medicine, CA (S.L.C.).
⁷ Department of Epidemiology and Population Health (T.L.A.).

^# Contributed equally.

No abstract available

Keywords: coronary artery disease; genetic predisposition to disease; genetic testing; low density lipoprotein; precision medicine; primary prevention; young adults.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adolescent
Cholesterol, HDL
Cholesterol, LDL
Coronary Artery Disease* / genetics
Humans
Risk Factors
Young Adult

Substances

Cholesterol, LDL
Cholesterol, HDL

Publication types

MeSH terms

Substances

Grants and funding