Glycyrrhiza polysaccharides inhibits PRRSV replication

Youbing Yang; Yongjian Liu; Ran Lou; Ying Lei; Gan Li; Zhiqian Xu; Xiangbin You

doi:10.1186/s12985-023-02052-9

Glycyrrhiza polysaccharides inhibits PRRSV replication

Virol J. 2023 Jul 5;20(1):140. doi: 10.1186/s12985-023-02052-9.

Authors

Youbing Yang^#^{1

2}, Yongjian Liu^#^{1

2}, Ran Lou^{1

2}, Ying Lei^{1

2}, Gan Li^{1

2}, Zhiqian Xu^{1

2}, Xiangbin You^{3

4}

Affiliations

¹ College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
² Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang, 471023, China.
³ College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China. yxb0710@163.com.
⁴ Luoyang Key Laboratory of Animal Genetics and Breeding, Luoyang, 471023, China. yxb0710@163.com.

^# Contributed equally.

Abstract

Glycyrrhiza polysaccharide (GCP) is a natural plant active polysaccharide extracted from traditional Chinese medicine licorice. In this research, we studied the antiviral activity of glycyrrhiza polysaccharide against porcine reproductive and respiratory syndrome virus (PRRSV), a virus of the Arteriviridae family, with a high rate of variation and has caused huge economic losses to the pig industry in various countries since its discovery. Our results show that GCP can inhibit PRRSV replication in a dose-dependent manner. Furthermore, GCP could inhibit the mRNA expression of receptor genes CD163 and NF-κB p65 and promote the mRNA expression of the SLA-7 gene. Because of these results, GCP can be used as a candidate drug to prevent and treat PRRS.

Keywords: CD163; Glycyrrhiza polysaccharide; NF-κB; PRRSV; SLA-7.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line
Glycyrrhiza*
Porcine Reproductive and Respiratory Syndrome*
Porcine respiratory and reproductive syndrome virus*
RNA, Messenger
Swine
Virus Replication

Substances

RNA, Messenger