Crosstalk between gut microbiota and RNA N6-methyladenosine modification in cancer

Hao Su; Henley Cheung; Harry Cheuk-Hay Lau; Hongyan Chen; Xiaoting Zhang; Na Qin; Yifei Wang; Matthew Tak Vai Chan; William Ka Kei Wu; Huarong Chen

doi:10.1093/femsre/fuad036

Crosstalk between gut microbiota and RNA N6-methyladenosine modification in cancer

FEMS Microbiol Rev. 2023 Jul 5;47(4):fuad036. doi: 10.1093/femsre/fuad036.

Authors

Hao Su^{1

2}, Henley Cheung¹, Harry Cheuk-Hay Lau¹, Hongyan Chen^{1

2}, Xiaoting Zhang^{1

2}, Na Qin^{1

2}, Yifei Wang³, Matthew Tak Vai Chan², William Ka Kei Wu^{1

2}, Huarong Chen^{1

2}

Affiliations

¹ Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong 99077, China.
² Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong 99077, China.
³ School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong 99077, China.

PMID: 37407433
DOI: 10.1093/femsre/fuad036

Abstract

The gut microbiota plays a crucial role in regulating various host metabolic, immune, and neuroendocrine functions, and has a significant impact on human health. Several lines of evidence suggest that gut dysbiosis is associated with a variety of diseases, including cancer. The gut microbiota can impact the development and progression of cancer through a range of mechanisms, such as regulating cell proliferation and death, modulating the host immune response, and altering the host metabolic state. Gene regulatory programs are considered critical mediators between the gut microbiota and host phenotype, of which RNA N6-methyladenosine (m6A) modifications have attracted much attention recently. Aberrant m6A modifications have been shown to play a crucial role in cancer development. This review aims to provide an overview of the diverse roles of gut microbiota and RNA m6A modifications in cancer and highlight their potential interactions in cancer development.

Keywords: N6-methyladenosine; cancer; crosstalk; microbiota.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Proliferation
Gastrointestinal Microbiome* / genetics
Humans
Neoplasms* / genetics
RNA

Substances

RNA