Chitosan and its derivatives in 3D/4D (bio) printing for tissue engineering and drug delivery applications

Tarun Agarwal; Irene Chiesa; Marco Costantini; Anna Lopamarda; Maria Celeste Tirelli; Om Prakash Borra; Subhash Venkata Sai Varshapally; Yanamadala Ashwin Vijay Kumar; G Koteswara Reddy; Carmelo De Maria; Lijie Grace Zhang; Tapas Kumar Maiti

doi:10.1016/j.ijbiomac.2023.125669

Chitosan and its derivatives in 3D/4D (bio) printing for tissue engineering and drug delivery applications

Int J Biol Macromol. 2023 Aug 15:246:125669. doi: 10.1016/j.ijbiomac.2023.125669. Epub 2023 Jul 3.

Affiliations

¹ Department of Bio-Technology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, AP, India. Electronic address: tarun3agarwal5@gmail.com.
² Research Center "E. Piaggio", Department of Information Engineering, University of Pisa, Largo Lucio Lazzarino 1, 56122 Pisa, Italy.
³ Institute of Physical Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland. Electronic address: mcostantini@ichf.edu.pl.
⁴ Institute of Physical Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland.
⁵ Department of Bio-Technology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, AP, India.
⁶ Research Center "E. Piaggio", Department of Information Engineering, University of Pisa, Largo Lucio Lazzarino 1, 56122 Pisa, Italy. Electronic address: carmelo.demaria@unipi.it.
⁷ Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA; Department of Electrical Engineering, The George Washington University, Washington, DC 20052, USA; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA; Department of Medicine, The George Washington University, Washington, DC 20052, USA.
⁸ Department of Biotechnology, Indian Institute of technology Kharagpur, West Bengal 721302, India.

PMID: 37406901
DOI: 10.1016/j.ijbiomac.2023.125669

Abstract

Tissue engineering research has undergone to a revolutionary improvement, thanks to technological advancements, such as the introduction of bioprinting technologies. The ability to develop suitable customized biomaterial inks/bioinks, with excellent printability and ability to promote cell proliferation and function, has a deep impact on such improvements. In this context, printing inks based on chitosan and its derivatives have been instrumental. Thus, the current review aims at providing a comprehensive overview on chitosan-based materials as suitable inks for 3D/4D (bio)printing and their applicability in creating advanced drug delivery platforms and tissue engineered constructs. Furthermore, relevant strategies to improve the mechanical and biological performances of this biomaterial are also highlighted.

Keywords: 3D/4D printing; Bioinks; Chitosan; Drug delivery; Tissue engineering.

Publication types

Review

MeSH terms

Biocompatible Materials
Chitosan*
Drug Delivery Systems
Printing, Three-Dimensional
Tissue Engineering*
Tissue Scaffolds

Substances

Chitosan
Biocompatible Materials