Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance

Marine Fidelle; Ai-Ling Tian; Laurence Zitvogel; Guido Kroemer

doi:10.1080/2162402X.2023.2224672

Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance

Oncoimmunology. 2023 Jun 29;12(1):2224672. doi: 10.1080/2162402X.2023.2224672. eCollection 2023.

Authors

Marine Fidelle^{1

2

3}, Ai-Ling Tian^{2

4}, Laurence Zitvogel^{1

3

5

6}, Guido Kroemer^{2

4

7}

Affiliations

¹ Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France.
² Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France.
³ Equipe Labellisée Par la Ligue Contre le Cancer, Inserm U1015, Villejuif, France.
⁴ Centre de Recherche des Cordeliers, Equipe Labellisée Par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.
⁵ Faculty of Medicine, Université Paris Saclay, France.
⁶ Department of Biology, Center of Clinical Investigations in Biotherapies of Cancer (CICBT) BIOTHERIS, Villejuif, France.
⁷ Department of Biology, Institut du Cancer Paris Carpem, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.

Abstract

In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM-1, thereby triggering the exodus of immunosuppressive T cells from gut-associated lymphoid tissues toward tumors.

Keywords: Cancer immunotherapy; Enterocloster; MAdCAM-1; bile acids; gut; immunosuppression; microbiota.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Bile Acids and Salts
Gastrointestinal Microbiome* / physiology
Humans
Monitoring, Immunologic
Neoplasms*
T-Lymphocytes

Substances

Bile Acids and Salts

Grants and funding

The work was supported by the Agence Nationale de la Recherche [Projets blancs]; Association pour la Recherche sur le Cancer Cancéropôle Ile de France Fondation Leducq Fondation pour la Recherche Médicale Institut National Du Cancer Institut Universitaire de France Ligue Contre le Cancer [EL2016.LNCC (VT/PLP)]; European Research Area Network on Cardiovascular Diseases (ERA-CVD, MINOTAUR) Gustave Roussy Odyssea the European Union Horizon 2020 Project Oncobiome Fondation Carrefour Inserm (HTE) the LabEx Immuno-Oncology [ANR-18-IDEX-0001]; the RHU Torino Lumière a donation by Elior Chancelerie des universités de Paris (Legs Poix) Association “Le Cancer du Sein, Parlons-en!” AMMICa US23/CNRS UMS3655 ANR under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases Agence Nationale de la Recherche (ANR) – Projets blancs the SIRIC Cancer Research and Personalized Medicine (CARPEM) Equipe labelisée LIGUE [EL2016.LNCC (VT/PLP)]; Immunolife [ANR-21-5 RHUS-0017]; the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE) Seerave Foundation.